Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

Blog Article

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic doorking 1835-080 DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs).The cGAS-STING signaling has multiple immunologic and physiological functions in all human vital organs.It mediates protective innate immune defense against DNA-containing pathogen infection, confers intrinsic antitumor immunity via detecting tumor-derived DNA, and gives rise to autoimmune and inflammatory diseases upon aberrant activation by cytosolic leakage of self-genomic and mitochondrial DNA.

Disruptions in these functions are associated with the pathophysiology of various immunologic and neurodegenerative diseases.Recent evidence indicates important roles of the cGAS-STING signaling in mediating inflammatory responses in ocular inflammatory and inflammation-associated diseases, such as keratitis, diabetic retinopathy, age-related macular degeneration, and uveitis.In this review, we summarize the recently emerging evidence of cGAS-STING signaling in mediating ocular inflammatory responses and affecting pathogenesis of these complex eye diseases.

We attempt to provide trufit wrist brace insightful perspectives on future directions of investigating cGAS-STING signaling in ocular inflammation.Understanding how cGAS-STING signaling is modulated to mediate ocular inflammatory responses would allow future development of novel therapeutic strategies to treat ocular inflammation and autoimmunity.